Infection by lyssavirus through contact with saliva of infected animal - usually dog or bat
incubation period varies from weeks to months

Prodrome very much like flu:

1. headaches
2. fever
3. general weakness
4. numbness or tingling around the bite
5. with progression to muscle spasms, fear of water, and convulsions.

Ultimately fatal in 100% cases when symptoms present.

1. early suspicion of exposure - human rabies immunoglobulin (HRIG)