=====supplements====
====Carnitine===
[[https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional/]]
  * synthesized endogenously in the liver, kidneys, and brain from the amino acids lysine and methionine
  * an essential cofactor that helps transport long-chain fatty acids into the mitochondria
  * also helps transport some toxic compounds out of the mitochondria
  *  a strict vegetarian diet, for example, synthesizes approximately 14.4 mg/day carnitine - dietary requirement 15mg/d
  * The study found that L-carnitine significantly reduced rates of all-cause mortality, ventricular arrhythmias, and new-onset angina but did not affect risk of heart failure or myocardial reinfarction 
  * 

====Creatine===

====pomegranate juice===
  *Pomegranate contains substantial amount of ellagitannins (a type of polyphenol)
  *polyphenols thought to have role in ACE inhibition as well as increasing NO levels

====Red Yeast Rice & statins===
  *contains monacolin K - has the same chemical structure as lovastatin
  *same action with same side effects
  *blocks liver HMG-CoA reductase to reduce cholesterol production
  *myopathy, hepatotoxicity, and diabetes mellitus being the most common adverse reactions
  *different statins metabolised differently - [[https://www.ncbi.nlm.nih.gov/books/NBK430940/| statin review]]
    *Fluvastatin, lovastatin, pravastatin, and simvastatin have a relatively short half-life.
    *atorvastatin and rosuvastatin have longer half-lives
    *HMG-CoA reductase inhibitors are excreted into bile and faeces
===Monacolin side effects:==
      *Digestive issues: Bloating, gas, heartburn, nausea, and stomach pain.
      *Headaches and dizziness: Mild neurological symptoms are frequently reported.
      *Muscle aches: Mild soreness and fatigue in muscles are common.

{{:wiki:metabolic:coq10pathway.png?400|}}

====CoEnzymeQ10====
[[https://www.mdpi.com/1422-0067/21/18/6695]]