supplements
Carnitine
https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional/
- synthesized endogenously in the liver, kidneys, and brain from the amino acids lysine and methionine
- an essential cofactor that helps transport long-chain fatty acids into the mitochondria
- also helps transport some toxic compounds out of the mitochondria
- a strict vegetarian diet, for example, synthesizes approximately 14.4 mg/day carnitine - dietary requirement 15mg/d
- The study found that L-carnitine significantly reduced rates of all-cause mortality, ventricular arrhythmias, and new-onset angina but did not affect risk of heart failure or myocardial reinfarction
Creatine
pomegranate juice
- Pomegranate contains substantial amount of ellagitannins (a type of polyphenol)
- polyphenols thought to have role in ACE inhibition as well as increasing NO levels
Red Yeast Rice & statins
- contains monacolin K - has the same chemical structure as lovastatin
- same action with same side effects
- blocks liver HMG-CoA reductase to reduce cholesterol production
- myopathy, hepatotoxicity, and diabetes mellitus being the most common adverse reactions
- different statins metabolised differently - statin review
- Fluvastatin, lovastatin, pravastatin, and simvastatin have a relatively short half-life.
- atorvastatin and rosuvastatin have longer half-lives
- HMG-CoA reductase inhibitors are excreted into bile and faeces
Monacolin side effects:
- Digestive issues: Bloating, gas, heartburn, nausea, and stomach pain.
- Headaches and dizziness: Mild neurological symptoms are frequently reported.
- Muscle aches: Mild soreness and fatigue in muscles are common.
