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        <title>My EM Notes</title>
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        <title>Barrett&#039;s Oesophagus</title>
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        <description>Barrett&#039;s Oesophagus

	* acquired condition as a response to gastro-oesophageal reflux which leads to a columnar lined distal oesophagus
	* risk increased: male, age, obesity, smoking, alcohol and frequency of reflux episodes
	* known association with transformation to adenocarcinoma</description>
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        <title>Biliary Disease</title>
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        <description>Biliary Disease

Cholelithiasis

	* 80% = cholesterol as major component
	* pain usually poorly localised
	* no systemic signs/symptoms
	* lab Ix - normal
	* USS preferred imaging modality, MRI if stone is thought to be in the duct (choledocholithiasis)</description>
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        <title>constipation</title>
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        <description>constipation</description>
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        <title>Diarrhoea</title>
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        <description>Diarrhoea

A change in stool consistency to watery or loose, with &gt;3 episodes or &gt;200g stool in 24/24.

	* Acute: &lt;14 days
	* Persistent: 14-30 days
	* Chronic: &gt;30 days

Differential Diagnosis for diarrhoeal illness is broad. Consider:

	* mesenteric ischemia</description>
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        <title>GORD</title>
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        <description>GORD

Gastro-Oesophageal Reflux Disease

	* Fundamental abnormality is incompetence of the oesophageal-gastric junction as an anti-reflux barrier
	* Peristaltic dysfunction becomes progressively more common going from non-erosive to erosive oesophagitis, to Barrett’s oesophagus.</description>
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        <dc:date>2023-04-25T12:16:08+00:00</dc:date>
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        <title>GI bleeding</title>
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        <description>GI bleeding

Upper GI bleed (UGIB)

	* Upper GI bleeding can be divided into variceal and non-variceal causes, because of important differences in Mx strategies

----------
 History    Likely cause NSAID use, previous ulcer,systemic illness  Peptic ulcer disease/gastroduodenitis</description>
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        <title>Acute Liver Failure</title>
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        <description>Acute Liver Failure

	* A specific term used to refer to:
		*  acute abnormality of Liver Function Tests in someone without underlying liver disease as opposed to Acute on Chronic Liver disease and others
		*  is associated with a coagulopathy which is different from the coagulopathy of sepsis. The coagulopathy required is determined as: INR &gt;1.5 or prolonged PT</description>
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        <dc:date>2023-04-25T12:16:08+00:00</dc:date>
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        <title>Hepatorenal Syndrome</title>
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        <description>Hepatorenal Syndrome

	* end-stage result of poor renal perfusion induced by increasingly severe hepatic injury.
		* usually portal hypertension due to cirrhosis, severe alcoholic hepatitis, or, less often, metastatic tumors

	* diagnosis of exclusion and associated with poor prognosis</description>
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        <dc:date>2023-04-25T12:16:08+00:00</dc:date>
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        <title>IBD</title>
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        <description>IBD

Inflammatory Bowel Disease

Ulcerative Colitis

	* a type of IBD that characteristically involves diffuse inflammation of the colonic mucosa, especially the rectum, but also variable lengths of the colon, in a relapsing, remitting course
	* considered a multifactorial polygenic disease, as the exact aetiology is still unknown but includes environmental factors, immune dysfunction, and genetic predisposition</description>
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        <title>Pancreatitis</title>
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        <description>Pancreatitis

	*  80% - alcohol or gall stone disease.
		* biliary tract disease is more common cause in women vs alcoholism in men

	*  recent excess alcohol, recent large meal.
	*  PHx of gall stones, mumps, drugs (thiazides, sulphonamides)
	*  Trauma</description>
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